Retrograde apoptotic signaling by the p75 neurotrophin receptor
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چکیده
منابع مشابه
Retrograde apoptotic signaling by the p75 neurotrophin receptor
Neurotrophins are target-derived factors necessary for mammalian nervous system development and maintenance. They are typically produced by neuronal target tissues and interact with their receptors at axonal endings. Therefore, locally generated neurotrophin signals must be conveyed from the axon back to the cell soma. Retrograde survival signaling by neurotrophin binding to Trk receptors has b...
متن کاملCD 271 (P75 neurotrophin receptor).
P75NTR (or CD271) is a member of the Tumor Necrosis Factor receptor (TNFR) super family of transmembrane proteins that share significant homology in their extracellular domains. Subsets of TNF receptors, including CD271, have a cytoplasmic death domain, although CD271 has unique intracellular structure and downstream signaling partners. CD271 is also differentiated from other members of the TNF...
متن کاملBex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle.
A screening for intracellular interactors of the p75 neurotrophin receptor (p75NTR) identified brain-expressed X-linked 1 (Bex1), a small adaptor-like protein of unknown function. Bex1 levels oscillated during the cell cycle, and preventing the normal cycling and downregulation of Bex1 in PC12 cells sustained cell proliferation under conditions of growth arrest, and inhibited neuronal different...
متن کاملDifferential role of the low affinity neurotrophin receptor (p75) in retrograde axonal transport of the neurotrophins
The receptor mechanisms mediating the retrograde axonal transport of the neurotrophins have been investigated in adult rats. We show that transport of the TrkB ligands NT-4 and BDNF to peripheral neurons is dependent on the low affinity neurotrophin receptor (LNR). Pharmacological manipulation of LNR in vivo using either an anti-LNR antibody or a soluble recombinant LNR extracellular domain com...
متن کاملLigand-independent signaling by disulfide-crosslinked dimers of the p75 neurotrophin receptor.
Dimerization is recognized as a crucial step in the activation of many plasma membrane receptors. However, a growing number of receptors pre-exist as dimers in the absence of ligand, indicating that, although necessary, dimerization is not always sufficient for signaling. The p75 neurotrophin receptor (p75(NTR)) forms disulfide-linked dimers at the cell surface independently of ligand binding t...
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ژورنال
عنوان ژورنال: Neuronal Signaling
سال: 2017
ISSN: 2059-6553
DOI: 10.1042/ns20160007